Science Behind NUNZIA™

Studies Supporting Nunzia

Evidence drawn from 300 studies over the last 20 years suggests that Anxiety Disorders are the basis of Autistic Spectrum Disorders (ASD).  They also indicate that these diagnoses may be connected to other neurodevelopmental conditions such as Fragile X Syndrome and Attention-Deficit/ Hyperactivity Disorder, along with the development of mental illnesses such as Post-Traumatic Stress Disorder, and/or Obsessive Compulsive Disorder. These studies also seem to suggest that some disorders such as Multiple Sclerosis, Parkinson’s Disease, and Dementia may exist on the same anxiety and glutamate based disorder spectrum.

California Biotech formulated NUNZIA™ to ease stress and promote wellness by naturally and safely balancing glutamate levels within the hippocampus, a distinctively curved sea-horse-shaped region of the brain that is directly involved in processes such as:

  • Forming new memories and connecting emotions and sensessuch as smell and soundto memories
  • Consolidating new memories
  • Emotional Responses
  • Navigation
  • Spatial Orientation
  • Anxiety regulation

Finding medications that work well for neurodivergent people and individuals with mental disorders can be quite difficult.  The trial and error "shot-gun" approach can feel exhausting and frustrating, and the broad-acting effects of common anti-anxiety medications can feel more akin to "chemical straitjackets" than tools that promote health and wellness
Unlike common medications, scientists at California Biotech formulated Nunzia™ to act as a “targeted blocker” by using a unique blend of herbal ingredients.  Some of these ingredients include adaptogenic herbs (such as Rhodalia Rosea Root and Ashwagandha Root) that naturally and safely adapt their functions within the body based upon the specific needs of each individual.
NUNZIA™ was developed to help ease symptoms of anxiety by reducing the overabundance of excitatory synapses. When there is a rapid firing of excitatory synapses and the protein filters of the brain are functional, then anxiety occurs with no or minimal fixations.  When the protein filters are not functional or functioning at full capacity, such as the FMRP protein, then anxiety can also produce fixations and other disorders that relate to fixations or compulsions. It was initially thought that the absence of an FMRP protein filter may be the root cause of Fragile X Syndrome and Autism, but current research indicates that while the FMRP protein filter is present in such individuals, it is either not functioning at full capacity or functioning at different levels in each person.  Therefore, it seems that the different levels of functionality of the FMRP protein filter could be the main cause of compulsive disorders with fixations.

Anxiety Symptoms and Disorders cause various problems alone, but when coupled with a malfunctioning FMRP protein filter the problems are exponential.

More information regarding neurodevelopmental conditions and mental illnesses are listed below:

Symptoms of Anxiety:
According to the Mayo Clinic Staff: ( Symptoms of Anxiety)

Common anxiety signs and symptoms include:

  • Feeling nervous
  • Feeling powerless
  • Having a sense of impending danger, panic or doom
  • Having an increased heart rate
  • Breathing rapidly (hyperventilation)
  • Sweating
  • Trembling
  • Feeling weak or tired
  • Trouble concentrating or thinking about anything other than the present worry

Several types of anxiety disorders exist:
Separation anxiety disorder is a childhood disorder characterized by anxiety that is excessive for the developmental level and related to separation from parents or others who have parental roles.

Selective mutism is a consistent failure to speak in certain situations, such as school, even when you can speak in other situations, such as at home with close family members. This can interfere with school, work and social functioning.

Specific phobias are characterized by major anxiety when you’re exposed to a specific object or situation and a desire to avoid it. Phobias provoke panic attacks in some people.
Social anxiety disorder (social phobia) involves high levels of anxiety, fear and avoidance of social situations due to feelings of embarrassment, self-consciousness and concern about being judged or viewed negatively by others.

Panic disorder involves repeated episodes of sudden feelings of intense anxiety and fear or terror that reach a peak within minutes (panic attacks). You may have feelings of impending doom, shortness of breath, heart palpitations or chest pain.

Agoraphobia is anxiety about, and often avoidance of, places or situations where you might feel trapped or helpless if you start to feel panicky or experience embarrassing symptoms, such as losing control.

Generalized anxiety disorder:
Includes persistent and excessive anxiety and worry about activities or events — even ordinary, routine issues. The worry is usually out of proportion to the actual circumstance, is difficult to control and interferes with your ability to focus on current tasks. It often occurs along with other anxiety disorders or depression.

Substance-induced anxiety disorder is characterized by prominent symptoms of anxiety or panic that are a direct result of abusing drugs, taking medications, being exposed to a toxic substance or withdrawal from drugs.

Anxiety disorder due to a medical condition includes prominent symptoms of anxiety or panic that are directly caused by a physical health problem.
Specified anxiety disorder and unspecified anxiety disorder are terms for anxiety or phobias that don’t meet the exact criteria for any other anxiety disorders but are significant enough to be distressing and disruptive.

Other Disorders that NUNZIA may help:
(source: Mayo Clinic Staff)

Factors that may increase the risk of developing or triggering obsessive-compulsive disorder include:

Family history: Having parents or other family members with the disorder can increase your risk of developing OCD stressful life events. If you’ve experienced traumatic or stressful events or you tend to react strongly to stress, your risk may increase. This reaction may, for some reason, trigger the intrusive thoughts, rituals and emotional distress characteristic of OCD.

Stressful events cause ANXIETY:

(source: Mayo Clinic Staff)
The cause of obsessive-compulsive disorder isn’t fully understood. Main theories include:

Biology: OCD may be a result of changes in your body’s own natural chemistry or brain functions. OCD may also have a genetic component, but specific genes have yet to be identified.

California Biotech identified the chemical functions that lead to Anxiety, which can trigger OCD.

Environment: Some environmental factors such as infections are suggested as a trigger for OCD, but more research is needed to be sure.

(source: Mayo Clinic Staff)
Individuals with obsessive-compulsive disorder may have additional problems. Some of the problems below may be associated with OCD.  Others may exist in addition to OCD, but not be caused by it. (NUNZIA™ may ease the symptoms of  blue bolded conditions.)

  • Inability to attend work, school or social activities
  • Troubled relationships
  • Overall poor quality of life
  • Anxiety disorders
  • Depression
  • Eating disorders
  • Suicidal thoughts and behavior
  • Alcohol or other substance abuse
  • Contact dermatitis from frequent hand-washing (if frequent hand–washing is a fixation)

General clinical implications

  • Autoimmunity and antibody interactions with glutamate receptors and their subunit genes
  • Excitotoxicity
  • Neurodegeneration

Conditions with demonstrated associations to glutamate receptors

  • Aching
  • Attention-Deficit/ Hyperactivity disorder (ADHD)*
  • Autism
  • Diabetes
  • Huntington’s disease
  • Ischemia
  • Multiple sclerosis
  • Parkinson’s disease (Parkinsonism)
  • Rasmussen’s encephalitis
  • Schizophrenia
  • Seizures
  • Other diseases suspected of glutamate receptor link
  • Neurodegenerative diseases with a suspected excitotoxicity link


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